The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age

نویسندگان

چکیده

Hypertension of SHR appears at an early age and progressively increases. This study aimed to evaluate the effect lycopene in with mild hypertension (young rats) or high level (adult rats). Four-weeks treatment 10 mg/kg/day decreased blood pressure young (from 144 ± 2 119 3 mmHg) adult 177 5 159 7 SHR. Heart renal hypertrophy fibrosis were increased compared lycopene, regardless rats, improved injury both organs. Although aging induced morphological functional alterations aorta, was only effective preventing former. Lycopene helped improve all parameters linked oxidative stress determined this study. In conclusion, age-associated harmful changes hypertension, cardiovascular remodelling, indicators oxidant-antioxidant systems

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ژورنال

عنوان ژورنال: Journal of Functional Foods

سال: 2021

ISSN: ['2214-9414', '1756-4646']

DOI: https://doi.org/10.1016/j.jff.2021.104656